DOCK1, dedicator of cytokinesis 1

DOCK1, dedicator of cytokinesis 1

• This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

• Gene Synonyms (dedicator of cytokinesis protein 1, 180 kDa protein downstream of CRK, DOwnstream of CrK, DOCK180, ced5,)
• NCBI Gene ID: 1793
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14185
  UNIPROT ID#>>B2RUU3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dedicator of cytokinesis 1 interacts with:

• ADP ribosylation factor like GTPase 4A
  BCAR1 scaffold protein, Cas family member
  beta-transducin repeat containing E3 ubiquitin protein ligase
  cullin 1
  cytohesin 2
  engulfment and cell motility 1
  engulfment and cell motility 2
  engulfment and cell motility 3
  estrogen receptor 2
  F-box and WD repeat domain containing 11
  growth factor receptor bound protein 2
  heterogeneous nuclear ribonucleoprotein L
  interaction protein for cytohesin exchange factors 1
  jumonji domain containing 6, arginine demethylase and lysine hydroxylase
  methylphosphate capping enzyme
  microtubule associated protein 1 light chain 3 beta
  NCK adaptor protein 2
  neurotrophic receptor tyrosine kinase 1
  protein kinase cAMP-activated catalytic subunit alpha
  protein tyrosine kinase 2
  Rac family small GTPase 1
  Rac family small GTPase 2
  SNW domain containing 1
  spindle apparatus coiled-coil protein 1
  SRC proto-oncogene, non-receptor tyrosine kinase
  survival motor neuron 1
  trafficking regulator and scaffold protein tamalin
  vir like m6A methyltransferase associated
  WASP family member 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.