DOCK2, dedicator of cytokinesis 2

DOCK2, dedicator of cytokinesis 2

• The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function. [provided by RefSeq, May 2018]

• Gene Synonyms (dedicator of cytokinesis protein 2, dedicator of cyto-kinesis 2, IMD40,)
• NCBI Gene ID: 1794
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q92608
  UNIPROT ID#>>Q5XG91
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dedicator of cytokinesis 2 interacts with:

• anterior gradient 2, protein disulphide isomerase family member
  autophagy related 16 like 1
  calcium binding and coiled-coil domain 2
  caspase recruitment domain family member 10
  cyclin D1 binding protein 1
  cysteine rich tail 1
  DDB1 and CUL4 associated factor 15
  decapping enzyme, scavenger
  engulfment and cell motility 1
  golgin A6 family like 9
  heterogeneous nuclear ribonucleoprotein K
  homeobox A1
  keratin 31
  keratin 34
  keratin 40
  keratin associated protein 10-1
  keratin associated protein 10-3
  keratin associated protein 10-7
  keratin associated protein 10-8
  keratin associated protein 10-9
  keratin associated protein 1-1
  keratin associated protein 12-3
  keratin associated protein 1-3
  keratin associated protein 17-1
  keratin associated protein 3-1
  keratin associated protein 3-3
  keratin associated protein 4-2
  keratin associated protein 5-7
  keratin associated protein 5-9
  keratin associated protein 9-2
  keratin associated protein 9-3
  keratin associated protein 9-4
  KH RNA binding domain containing, signal transduction associated 1
  KH RNA binding domain containing, signal transduction associated 2
  KH RNA binding domain containing, signal transduction associated 3
  metadherin
  microtubule associated scaffold protein 2
  minichromosome maintenance complex component 2
  MyoD family inhibitor
  NBPF member 19
  notch 2 N-terminal like A
  p21 (RAC1) activated kinase 2
  phospholipid scramblase 1
  pleckstrin homology and FYVE domain containing 2
  proprotein convertase subtilisin/kexin type 5
  Rac family small GTPase 1
  Rac family small GTPase 2
  SNW domain containing 1
  telomeric repeat binding factor 1
  teneurin transmembrane protein 4
  transglutaminase 1
  vav guanine nucleotide exchange factor 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.