DOCK3, dedicator of cytokinesis 3

DOCK3, dedicator of cytokinesis 3

• This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]

• Gene Synonyms (dedicator of cytokinesis protein 3, modifier of cell adhesion, presenilin-binding protein, MOCA, NEDIDHA, PBP,)
• NCBI Gene ID: 1795
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IZD9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dedicator of cytokinesis 3 interacts with:

• engulfment and cell motility 1
  engulfment and cell motility 3
  homeobox A1
  KH RNA binding domain containing, signal transduction associated 1
  nuclear receptor subfamily 3 group C member 1
  pleckstrin homology and FYVE domain containing 2
  presenilin 1
  presenilin 2
  SRSF protein kinase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.