IBA57, iron-sulfur cluster assembly factor IBA57

IBA57, iron-sulfur cluster assembly factor IBA57

• The protein encoded by this gene localizes to the mitochondrion and is part of the iron-sulfur cluster assembly pathway. The encoded protein functions late in the biosynthesis of mitochondrial 4Fe-4S proteins. Defects in this gene have been associated with autosomal recessive spastic paraplegia-74 and with multiple mitochondrial dysfunctions syndrome-3. Two transcript variants encoding different isoforms have been found for this gene. The smaller isoform is not likely to be localized to the mitochondrion since it lacks the amino-terminal transit peptide. [provided by RefSeq, Jul 2015]

• Gene Synonyms (putative transferase CAF17, mitochondrial, IBA57 homolog, iron-sulfur cluster assembly, IBA57, iron-sulfur cluster assembly homolog, iron-sulfur cluster assembly factor for biotin synthase- and aconitase-like mitochondrial proteins, with a mass of 57kDa, putative transferase C1orf69, mitochondrial, C1orf69, MMDS3, SPG74,)
• NCBI Gene ID: 200205
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4E1G9
  UNIPROT ID#>>Q5T440
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

iron-sulfur cluster assembly factor IBA57 interacts with:

• mitochondrial contact site and cristae organizing system subunit 10
  oxidoreductase like domain containing 1
  transmembrane protein 184A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.