PHF8, PHD finger protein 8

PHF8, PHD finger protein 8

• The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]

• Gene Synonyms (JHDM1F, KDM7B, MRXSSD, ZNF422, histone lysine demethylase PHF8, [histone H3]-dimethyl-L-lysine(36) demethylase PHF8, [histone H3]-dimethyl-L-lysine(9) demethylase PHF8, jumonji C domain-containing histone demethylase 1F,)
• NCBI Gene ID: 23133
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95327
  UNIPROT ID#>>Q9UPP1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

PHD finger protein 8 interacts with:

• anaphase promoting complex subunit 1
  anaphase promoting complex subunit 2
  anaphase promoting complex subunit 4
  anaphase promoting complex subunit 5
  anaphase promoting complex subunit 7
  BRCA1 associated ATM activator 1
  bromodomain containing 7
  cell division cycle 26
  cyclic GMP-AMP synthase
  deoxynucleotidyltransferase terminal interacting protein 2
  egl-9 family hypoxia inducible factor 3
  fizzy and cell division cycle 20 related 1
  H3.5 histone
  hook microtubule tethering protein 3
  La ribonucleoprotein 7, transcriptional regulator
  LSM family member 14B
  mitochondrial ribosomal protein S15
  mitochondrial ribosomal protein S35
  nucleolar pre-rRNA processing protein NIP7
  nucleolar protein 8
  obscurin like cytoskeletal adaptor 1
  phosphatidylinositol 4-kinase type 2 alpha
  pleckstrin homology domain containing A4
  regulator of chromosome condensation 2
  replication timing regulatory factor 1
  ring finger protein 123
  RNA polymerase II associated protein 1
  THAP domain containing 11
  UPF3A regulator of nonsense mediated mRNA decay

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.