AMACR, alpha-methylacyl-CoA racemase

AMACR, alpha-methylacyl-CoA racemase

• This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]

• Gene Synonyms (alpha-methylacyl-CoA racemase, 2-methylacyl-CoA racemase, AMACRD, CBAS4, P504S, RACE, RM,)
• NCBI Gene ID: 23600
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UHK6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

alpha-methylacyl-CoA racemase interacts with:

• centrosomal protein 152
  DDB1 and CUL4 associated factor 4
  proteasome assembly chaperone 3
  proteasome assembly chaperone 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.