MKRN1, makorin ring finger protein 1

MKRN1, makorin ring finger protein 1

• This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

• Gene Synonyms (E3 ubiquitin-protein ligase makorin-1, RING finger protein 61, RING-type E3 ubiquitin transferase makorin-1, RNF61,)
• NCBI Gene ID: 23608
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UHC7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

makorin ring finger protein 1 interacts with:

• argonaute RISC catalytic subunit 2
  ataxin 2-like
  ATPase family, AAA domain containing 3A
  cancer susceptibility candidate 3
  casein kinase 1 gamma 1
  cell cycle associated protein 1
  cleavage and polyadenylation specific factor 6
  DEAD box helicase 1
  dual specificity phosphatase 23
  eukaryotic translation initiation factor 4, gamma 1
  FAM161 centrosomal protein A
  family with sequence similarity 98, member A
  FIP1 like 1 (S. cerevisiae)
  GTPase activating protein (SH3 domain) binding protein 1
  GTPase activating protein (SH3 domain) binding protein 2
  heterogeneous nuclear ribonucleoprotein A2/B1
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein F
  heterogeneous nuclear ribonucleoprotein U
  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
  insulin-like growth factor 2 mRNA binding protein 1
  insulin-like growth factor 2 mRNA binding protein 3
  interleukin enhancer binding factor 2
  La ribonucleoprotein domain family, member 1
  La ribonucleoprotein domain family, member 4
  La ribonucleoprotein domain family, member 4B
  lin-28 homolog A (C. elegans)
  LINE-1 type transposase domain containing 1
  LUC7 like
  LUC7 like 2, pre-mRNA splicing factor
  makorin, ring finger protein, 1
  maturin, neural progenitor differentiation regulator homolog
  microtubule associated protein 1 light chain 3 beta
  NOP53 ribosome biogenesis factor
  nuclear fragile X mental retardation protein interacting protein 2
  OTU deubiquitinase, ubiquitin aldehyde binding 2
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein, nuclear 1
  proline-rich coiled-coil 2C
  RNA binding fox-1 homolog 1
  RNA transcription, translation and transport factor
  serrate RNA effector molecule homolog (Arabidopsis)
  Smad nuclear interacting protein 1
  synaptotagmin binding, cytoplasmic RNA interacting protein
  transformer 2 alpha homolog
  ubiquitin associated and SH3 domain containing A
  ubiquitin conjugating enzyme E2 D4 (putative)
  ubiquitin conjugating enzyme E2 W
  YOD1 deubiquitinase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.