SLC7A11, solute carrier family 7 member 11

SLC7A11, solute carrier family 7 member 11

• This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

• Gene Synonyms (cystine/glutamate transporter, amino acid transport system xc-, calcium channel blocker resistance protein CCBR1, solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11, solute carrier family 7, (cationic amino acid transporter, y+ system) member 11, CCBR1, xCT,)
• NCBI Gene ID: 23657
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UPY5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

solute carrier family 7 member 11 interacts with:

• keratin associated protein 1-1
  keratin associated protein 1-3
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  tetratricopeptide repeat domain 30B
  transmembrane protein 17

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.