G6PC, glucose-6-phosphatase catalytic subunit

G6PC, glucose-6-phosphatase catalytic subunit

• Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011]

• Gene Synonyms (G6PC1, G6PT, G6Pase, GSD1, GSD1a, glucose-6-phosphatase, G-6-Pase, G6Pase-alpha, glucose-6-phosphatase alpha,)
• NCBI Gene ID: 2538
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P35575
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glucose-6-phosphatase catalytic subunit interacts with:

• NSL1 component of MIS12 kinetochore complex
  sorting nexin 13

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