DNAI1, dynein axonemal intermediate chain 1

DNAI1, dynein axonemal intermediate chain 1

• This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

• Gene Synonyms (CILD1, DIC1, ICS1, PCD, dynein intermediate chain 1, axonemal, dynein, axonemal, intermediate polypeptide 1, immotile cilia syndrome 1, testis tissue sperm-binding protein Li 87P,)
• NCBI Gene ID: 27019
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VJI0
  UNIPROT ID#>>Q9UI46
  UNIPROT ID#>>A0A087WWV9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dynein axonemal intermediate chain 1 interacts with:

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