SALL3, spalt like transcription factor 3

SALL3, spalt like transcription factor 3

• This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis. [provided by RefSeq, Oct 2011]

• Gene Synonyms (sal-like protein 3, C2H2 zinc finger protein SALL3, epididymis secretory sperm binding protein, hSALL3, spalt-like zinc finger protein, zinc finger protein 796, ZNF796,)
• NCBI Gene ID: 27164
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A9JR48
  UNIPROT ID#>>Q9BXA9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

spalt like transcription factor 3 interacts with:

• cereblon
  chromodomain helicase DNA binding protein 7
  Nanog homeobox

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