NFU1, NFU1 iron-sulfur cluster scaffold

NFU1, NFU1 iron-sulfur cluster scaffold

• This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctions syndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

• Gene Synonyms (NFU1 iron-sulfur cluster scaffold homolog, mitochondrial, HIRA-interacting protein 5, NifU-like C-terminal domain containing, iron-sulfur cluster scaffold protein, CGI-33, HIRIP, HIRIP5, MMDS1, NIFUC, Nfu, NifU,)
• NCBI Gene ID: 27247
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UMS0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NFU1 iron-sulfur cluster scaffold interacts with:

• abhydrolase domain containing 10, depalmitoylase
  angiotensin II receptor associated protein
  CKLF like MARVEL transmembrane domain containing 5
  cutA divalent cation tolerance homolog
  desumoylating isopeptidase 2
  dual specificity phosphatase 13
  FKBP prolyl isomerase 7
  HtrA serine peptidase 2
  MORN repeat containing 3
  nitric oxide associated 1
  protein kinase, AMP-activated, alpha 1 catalytic subunit
  rhomboid domain containing 2
  zinc finger and SCAN domain containing 5A
  zinc finger protein 688

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.