GCLC, glutamate-cysteine ligase catalytic subunit

GCLC, glutamate-cysteine ligase catalytic subunit

• Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]

• Gene Synonyms (glutamate--cysteine ligase catalytic subunit, GCS heavy chain, gamma-ECS, gamma-glutamylcysteine synthetase, GCL, GCS, GLCL, GLCLC,)
• NCBI Gene ID: 2729
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14TF0
  UNIPROT ID#>>P48506
  UNIPROT ID#>>E1CEI4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glutamate-cysteine ligase catalytic subunit interacts with:

• C-C motif chemokine ligand 22
  dehydrogenase/reductase 11
  diphthamide biosynthesis 5
  glutamate-cysteine ligase modifier subunit
  NMD3 ribosome export adaptor
  PAX interacting protein 1
  peptidylprolyl isomerase D
  staufen double-stranded RNA binding protein 1
  tRNA-yW synthesizing protein 3 homolog

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.