SNX15, sorting nexin 15

SNX15, sorting nexin 15

• This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]

• Gene Synonyms (sorting nexin-15, clone iota unknown protein, HSAF001435,)
• NCBI Gene ID: 29907
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NRS6
  UNIPROT ID#>>E5KQS5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sorting nexin 15 interacts with:

• DDB1 and CUL4 associated factor 15
  methyltransferase like 14
  receptor accessory protein 6
  reticulon 4
  store-operated calcium entry associated regulatory factor
  vacuolar protein sorting 36 homolog

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.