CFHR1, complement factor H related 1

CFHR1, complement factor H related 1

• This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]

• Gene Synonyms (complement factor H-related protein 1, H factor (complement)-like 1, H factor (complement)-like 2, H-factor-like 1, complement factor H-related 1 pseudogene, h factor-like protein 1, CFHL, CFHL1, CFHL1P, CFHR1P, FHR-1, FHR1, H36, H36-1, H36-2, HFL1, HFL2,)
• NCBI Gene ID: 3078
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q03591
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

complement factor H related 1 interacts with:

• complement factor H related 2
  lipopolysaccharide binding protein
  peroxiredoxin 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.