ERVW-1, endogenous retrovirus group W member 1, envelope

ERVW-1, endogenous retrovirus group W member 1, envelope

• Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

• Gene Synonyms (syncytin-1, HERV-7q envelope protein, HERV-W Env glycoprotein, HERV-W envelope protein, HERV-W_7q21.2 provirus ancestral Env polyprotein, HERV-tryptophan envelope protein, endogenous retroviral family W, env(C7), member 1, endogenous retrovirus group W member 1, envelope glycoprotein, envelope polyprotein gPr73, enverin, human endogenous retrovirus W envC7-1 envelope protein, ENV, ENVW, ERVWE1, HERV-7q, HERV-W-ENV, HERV7Q, HERVW, HERVWENV,)
• NCBI Gene ID: 30816
• Species: Homo sapiens (Human)
• UNIPROT ID#>>D0EYG5
  UNIPROT ID#>>Q9UQF0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

endogenous retrovirus group W member 1, envelope interacts with:

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.