HLA-DQB1, major histocompatibility complex, class II, DQ beta 1

HLA-DQB1, major histocompatibility complex, class II, DQ beta 1

• HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

• Gene Synonyms (HLA class II histocompatibility antigen, DQ beta 1 chain, MHC class II DQ beta chain, MHC class II HLA-DQ beta glycoprotein, MHC class II antigen DQB1, MHC class II antigen HLA-DQ-beta-1, CELIAC1, HLA-DQB, IDDM1,)
• NCBI Gene ID: 3119
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5SU54
  UNIPROT ID#>>P01920
  UNIPROT ID#>>Q5Y7D3
  UNIPROT ID#>>Q5Y7A9
  UNIPROT ID#>>Q5Y7D6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

major histocompatibility complex, class II, DQ beta 1 interacts with:

• insulin

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