RSPO2, R-spondin 2

RSPO2, R-spondin 2

• This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

• Gene Synonyms (CRISTIN2, HHRRD, TETAMS2, R-spondin-2, R-spondin 2 homolog, roof plate-specific spondin-2,)
• NCBI Gene ID: 340419
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6UXX9
  UNIPROT ID#>>B3KVP3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

R-spondin 2 interacts with:

• cysteine rich tail 1
  keratin associated protein 10-1
  keratin associated protein 10-4
  keratin associated protein 10-6
  keratin associated protein 10-7
  keratin associated protein 10-9
  keratin associated protein 12-3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.