INPPL1, inositol polyphosphate phosphatase like 1

INPPL1, inositol polyphosphate phosphatase like 1

• The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]

• Gene Synonyms (phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, OPSMD, SHIP2, 51C protein, INPPL-1, SH2 domain-containing inositol-5'-phosphatase 2, SHIP-2, protein 51C,)
• NCBI Gene ID: 3636
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O15357
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

inositol polyphosphate phosphatase like 1 interacts with:

• acyl-CoA thioesterase 12
  ADP ribosylation factor GTPase activating protein 1
  alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
  ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
  ATPase H+ transporting V0 subunit d1
  BCAR1 scaffold protein, Cas family member
  betaine--homocysteine S-methyltransferase 2
  CD2 associated protein
  chaperonin containing TCP1 subunit 3
  cytosolic iron-sulfur assembly component 3
  dihydropyrimidinase like 5
  exportin 1
  HID1 domain containing
  insulin receptor
  integrin subunit alpha 4
  IQ motif containing GTPase activating protein 1
  keratin 1
  keratin 10
  keratin 14
  keratin 16
  keratin 17
  keratin 2
  keratin 3
  keratin 5
  keratin 6B
  keratin 6C
  keratin 73
  keratin 79
  keratin 9
  kinesin family member 15
  leucine rich repeat kinase 1
  LSM1 homolog, mRNA degradation associated
  mast cell immunoglobulin like receptor 1
  MET proto-oncogene, receptor tyrosine kinase
  methylcrotonoyl-CoA carboxylase 2
  minichromosome maintenance complex component 4
  mitochondrial carrier 2
  mitogen-activated protein kinase kinase kinase 13
  myeloid leukemia factor 2
  neurotrophic receptor tyrosine kinase 1
  nuclear RNA export factor 1
  perilipin 5
  phosphate cytidylyltransferase 2, ethanolamine
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoinositide-3-kinase regulatory subunit 2
  pleckstrin 2
  POP1 homolog, ribonuclease P/MRP subunit
  propionyl-CoA carboxylase subunit beta
  protein phosphatase 4 regulatory subunit 2
  protein phosphatase, Mg2+/Mn2+ dependent 1A
  ribonuclease P/MRP subunit p30
  ribonucleotide reductase regulatory subunit M2
  ribonucleotide reductase regulatory TP53 inducible subunit M2B
  ribosomal protein lateral stalk subunit P0
  ribosomal protein S19
  RNA polymerase II subunit M
  SH2B adaptor protein 2
  SH3 domain containing kinase binding protein 1
  SHC adaptor protein 1
  signal transducer and activator of transcription 2
  solute carrier family 1 member 1
  solute carrier family 22 member 9
  sorbin and SH3 domain containing 1
  sorbin and SH3 domain containing 3
  SRC proto-oncogene, non-receptor tyrosine kinase
  sterile alpha motif domain containing 4A
  TPD52 like 2
  transmembrane protein 184B
  tripartite motif containing 25
  tubulin alpha 1b
  tubulin beta 2B class IIb
  tubulin beta 3 class III
  tubulin beta 4B class IVb
  tubulin beta 6 class V
  tubulin beta class I
  ubiquitin associated and SH3 domain containing B
  ubiquitin C
  vascular cell adhesion molecule 1
  WW domain containing oxidoreductase
  X-linked Kx blood group
  zinc finger CCHC-type containing 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.