ITIH1, inter-alpha-trypsin inhibitor heavy chain 1

ITIH1, inter-alpha-trypsin inhibitor heavy chain 1

• This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. [provided by RefSeq, Nov 2015]

• Gene Synonyms (H1P, IATIH, IGHEP1, ITI-HC1, ITIH, SHAP, inter-alpha-trypsin inhibitor heavy chain H1, ITI heavy chain H1, inter-alpha (globulin) inhibitor, H1 polypeptide, inter-alpha-inhibitor heavy chain 1, inter-alpha-trypsin inhibitor complex component III, serum-derived hyaluronan-associated protein,)
• NCBI Gene ID: 3697
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P19827
  UNIPROT ID#>>B7Z8B6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

inter-alpha-trypsin inhibitor heavy chain 1 interacts with:

• phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  SRY-box transcription factor 4
  SUMO specific peptidase 2
  translocase of outer mitochondrial membrane 40

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.