ITIH4, inter-alpha-trypsin inhibitor heavy chain 4

ITIH4, inter-alpha-trypsin inhibitor heavy chain 4

• The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

• Gene Synonyms (GP120, H4P, IHRP, ITI-HC4, ITIHL1, PK-120, PK120, inter-alpha-trypsin inhibitor heavy chain H4, ITI heavy chain H4, inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein), inter-alpha-inhibitor heavy chain 4, inter-alpha-trypsin inhibitor family heavy chain-related protein, inter-alpha-trypsin inhibitor heavy chain family member 4, inter-alpha-trypsin inhibitor, heavy chain-like, 1, plasma kallikrein-sensitive glycoprotein 120,)
• NCBI Gene ID: 3700
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14624
  UNIPROT ID#>>B7ZKJ8
  UNIPROT ID#>>B2RMS9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

inter-alpha-trypsin inhibitor heavy chain 4 interacts with:

• DnaJ heat shock protein family (Hsp40) member C1
  kallikrein 1
  nuclear receptor subfamily 2 group C member 2
  staufen double-stranded RNA binding protein 1
  tumor protein p63

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.