KCNJ1, potassium inwardly rectifying channel subfamily J member 1

KCNJ1, potassium inwardly rectifying channel subfamily J member 1

• Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (KIR1.1, ROMK, ROMK1, ATP-sensitive inward rectifier potassium channel 1, ATP-regulated potassium channel ROM-K, inward rectifier K(+) channel Kir1.1, inwardly rectifying K+ channel, potassium channel, inwardly rectifying subfamily J member 1, potassium voltage-gated channel subfamily J member 1,)
• NCBI Gene ID: 3758
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A8K432
  UNIPROT ID#>>P48048
  UNIPROT ID#>>A0A024R3K6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

potassium inwardly rectifying channel subfamily J member 1 interacts with:

• protein kinase C delta
  serum/glucocorticoid regulated kinase 1
  SH3 domain containing ring finger 1
  SLC9A3 regulator 1
  SLC9A3 regulator 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.