LAMA2, laminin subunit alpha 2

LAMA2, laminin subunit alpha 2

• Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (LAMM, MDC1A, laminin subunit alpha-2, laminin M chain, laminin, alpha 2, laminin-12 subunit alpha, laminin-2 subunit alpha, laminin-4 subunit alpha, merosin heavy chain, mutant laminin subunit alpha 2,)
• NCBI Gene ID: 3908
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q59H37
  UNIPROT ID#>>P24043
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

laminin subunit alpha 2 interacts with:

• N(alpha)-acetyltransferase 10, NatA catalytic subunit
  pleckstrin homology domain containing A4
  ribosomal protein SA
  structural maintenance of chromosomes 6
  TEPSIN adaptor related protein complex 4 accessory protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.