LASP1, LIM and SH3 protein 1

LASP1, LIM and SH3 protein 1

• This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]

• Gene Synonyms (Lasp-1, MLN50, LIM and SH3 domain protein 1, metastatic lymph node gene 50 protein,)
• NCBI Gene ID: 3927
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14847
  UNIPROT ID#>>A0A024R1S8
  UNIPROT ID#>>B4DIC4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

LIM and SH3 protein 1 interacts with:

• ACD shelterin complex subunit and telomerase recruitment factor
  actin related protein 3
  adaptor related protein complex 3 subunit mu 1
  ADP ribosylation factor GTPase activating protein 1
  AHNAK nucleoprotein
  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
  ankyrin repeat and sterile alpha motif domain containing 1A
  apoptosis inhibitor 5
  ataxin 1
  AT-rich interaction domain 5A
  autophagy related 16 like 1
  BAG cochaperone 4
  basic helix-loop-helix family member e40
  BICD cargo adaptor 2
  bromo adjacent homology domain containing 1
  calcium homeostasis endoplasmic reticulum protein
  catenin alpha 3
  cation channel sperm associated 1
  centrosomal protein 170
  cerebral endothelial cell adhesion molecule
  chromosome 11 open reading frame 65
  chromosome 14 open reading frame 119
  chromosome 19 open reading frame 54
  cleavage stimulation factor subunit 2 tau variant
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  cyclin dependent kinase 12
  cysteine rich tail 1
  DAZ associated protein 2
  DDB1 and CUL4 associated factor 15
  deltex E3 ubiquitin ligase 2
  DNA polymerase delta 1, catalytic subunit
  docking protein 6
  double PHD fingers 2
  doublesex and mab-3 related transcription factor 3
  dynein axonemal assembly factor 2
  elongation factor Tu GTP binding domain containing 2
  euchromatic histone lysine methyltransferase 2
  even-skipped homeobox 2
  ezrin
  family with sequence similarity 168 member A
  family with sequence similarity 168 member B
  Fanconi anemia, complementation group C
  Fas binding factor 1
  F-box protein 17
  FMR1 autosomal homolog 2
  forkhead box H1
  forty-two-three domain containing 1
  G3BP stress granule assembly factor 2
  galectin 1
  glial cells missing transcription factor 2
  glutamine rich 1
  guanylyl cyclase domain containing 1
  H3 clustered histone 1
  HCLS1 associated protein X-1
  hepatocyte growth factor-regulated tyrosine kinase substrate
  integrator complex subunit 11
  keratin associated protein 10-8
  keratin associated protein 12-4
  keratin associated protein 19-3
  keratin associated protein 19-4
  keratin associated protein 19-6
  keratin associated protein 26-1
  keratin associated protein 3-2
  keratin associated protein 3-3
  keratin associated protein 4-2
  keratin associated protein 6-2
  leucine zipper tumor suppressor 2
  leukocyte receptor cluster member 8
  LIM domain only 4
  makorin ring finger protein 3
  mediator complex subunit 25
  microtubule associated protein 4
  MYC proto-oncogene, bHLH transcription factor
  MyoD family inhibitor
  myosin IC
  N-acetyltransferase 10
  NADPH oxidase activator 1
  nuclear receptor corepressor 2
  nuclear RNA export factor 1
  nuclear transcription factor Y subunit alpha
  nuclear transport factor 2
  nucleolin
  olfactory receptor family 10 subfamily H member 3
  orthodenticle homeobox 1
  oxoeicosanoid receptor 1
  paired like homeodomain 1
  phosphoglycerate kinase 1
  phospholipid scramblase 1
  pleckstrin homology domain containing A4
  POU class 1 homeobox 1
  proline rich 20A
  proline rich 20B
  proline rich 20C
  proline rich 20D
  proline rich 20E
  proline rich 35
  proteasome 20S subunit alpha 3
  protection of telomeres 1
  protein disulfide isomerase family A member 5
  protein kinase C, zeta
  protein kinase cAMP-dependent type II regulatory subunit beta
  protein kinase cGMP-dependent 1
  protein kinase cGMP-dependent 2
  protein kinase, cAMP dependent, catalytic, alpha
  protein kinase, cGMP-dependent, type I
  protein phosphatase 1 regulatory subunit 32
  protein phosphatase 6 catalytic subunit
  REL proto-oncogene, NF-kB subunit
  retinol dehydrogenase 12
  Rho guanine nucleotide exchange factor 15
  Rho guanine nucleotide exchange factor 16
  Rhox homeobox family member 2
  ring finger protein 38
  RNA binding fox-1 homolog 1
  RNA binding protein, mRNA processing factor
  RNA binding protein, mRNA processing factor 2
  septin 3
  SH2 domain containing 2A
  signal transducer and activator of transcription 3
  small nuclear ribonucleoprotein U4/U6.U5 subunit 27
  snail family transcriptional repressor 1
  sodium channel and clathrin linker 1
  solute carrier family 25 member 32
  solute carrier family 25 member 44
  spectrin alpha, non-erythrocytic 1
  sperm associated antigen 8
  sprouty RTK signaling antagonist 2
  T cell leukemia homeobox 3
  taste 2 receptor member 41
  tektin 3
  tektin 4
  tektin 5
  telomeric repeat binding factor 1
  tensin 2
  TERF1 interacting nuclear factor 2
  testin LIM domain protein
  THAP domain containing 1
  THAP domain containing 8
  thyroid hormone receptor interactor 13
  TNFAIP3 interacting protein 2
  trafficking from ER to golgi regulator
  transcription factor 4
  tripartite motif containing 25
  tripartite motif containing 27
  tripartite motif containing 28
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 2
  ubiquitin like with PHD and ring finger domains 1
  UFM1 specific peptidase 1 (inactive)
  VAC14 component of PIKFYVE complex
  vascular endothelial zinc finger 1
  vestigial like family member 3
  VPS37C subunit of ESCRT-I
  WW domain containing oxidoreductase
  YES proto-oncogene 1, Src family tyrosine kinase
  YTH N6-methyladenosine RNA binding protein 1
  zinc finger and BTB domain containing 9
  zinc finger C2HC-type containing 1A
  zinc finger CCCH-type containing 10
  zinc finger DHHC-type palmitoyltransferase 17
  zinc finger protein 764
  zyxin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.