MNDA, myeloid cell nuclear differentiation antigen

MNDA, myeloid cell nuclear differentiation antigen

• The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]

• Gene Synonyms (PYHIN3, myeloid cell nuclear differentiation antigen, epididymis secretory sperm binding protein,)
• NCBI Gene ID: 4332
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5VUU6
  UNIPROT ID#>>P41218
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

myeloid cell nuclear differentiation antigen interacts with:

• F-box protein 7
  mitogen-activated protein kinase 8 interacting protein 2
  nuclear receptor binding SET domain protein 3
  protein arginine methyltransferase 6
  protein arginine methyltransferase 7
  RB transcriptional corepressor 1
  RB transcriptional corepressor like 2
  signal transducer and activator of transcription 3
  tumor protein p53

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.