MYO7A, myosin VIIA

MYO7A, myosin VIIA

• This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

• Gene Synonyms (DFNA11, DFNB2, MYOVIIA, MYU7A, NSRD2, USH1B, unconventional myosin-VIIa, myosin VIIA (Usher syndrome 1B (autosomal recessive, severe)),)
• NCBI Gene ID: 4647
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13402
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

myosin VIIA interacts with:

• cadherin related 23
  cullin 9
  kelch like ECH associated protein 1
  KH RNA binding domain containing, signal transduction associated 1
  LanC like 1
  myosin VIIA and Rab interacting protein
  protein kinase cAMP-dependent type I regulatory subunit alpha
  RHO family interacting cell polarization regulator 1
  ring finger protein 123
  USH1 protein network component harmonin
  vezatin, adherens junctions transmembrane protein
  whirlin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.