NPPB, natriuretic peptide B

NPPB, natriuretic peptide B

• This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]

• Gene Synonyms (BNP, natriuretic peptides B, brain type natriuretic peptide, gamma-brain natriuretic peptide, natriuretic peptide precursor B, natriuretic protein,)
• NCBI Gene ID: 4879
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P16860
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

natriuretic peptide B interacts with:

• cysteine rich tail 1
  gem nuclear organelle associated protein 4
  histone deacetylase 4
  keratin 40
  keratin associated protein 10-3
  keratin associated protein 10-9
  natriuretic peptide receptor 1
  natriuretic peptide receptor 2
  natriuretic peptide receptor 3
  notch 2 N-terminal like A
  proteasome 20S subunit alpha 3
  SERTA domain containing 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.