TNFRSF11B, TNF receptor superfamily member 11b

TNFRSF11B, TNF receptor superfamily member 11b

• The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (OCIF, OPG, PDB5, TR1, tumor necrosis factor receptor superfamily member 11B, osteoclastogenesis inhibitory factor, osteoprotegerin, tumor necrosis factor receptor superfamily, member 11b,)
• NCBI Gene ID: 4982
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O00300
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TNF receptor superfamily member 11b interacts with:

• thrombospondin 1
  TNF superfamily member 10
  TNF superfamily member 11
  TNF superfamily member 13
  vitronectin
  von Willebrand factor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.