- Gene Overview
- Interaction Network
- Sequence Verification
OPRL1, opioid related nociceptin receptor 1
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The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
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Gene Synonyms (KOR-3, KOR3, NOCIR, NOP, NOPr, OOR, OPRL, ORL1, nociceptin receptor, kappa-type 3 opioid receptor, kappa3-related opioid receptor, nociceptin/orphanin FQ receptor, opiate receptor-like 1, orphanin FQ receptor,)
- NCBI Gene ID:
4987
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>P41146
UNIPROT ID#>>Q8IXB0
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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opioid related nociceptin receptor 1 interacts with:
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