P2RX7, purinergic receptor P2X 7

P2RX7, purinergic receptor P2X 7

• The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]

• Gene Synonyms (P2X7, P2X purinoceptor 7, ATP receptor, P2X7 receptor, P2Z receptor, purinergic receptor P2X, ligand gated ion channel, 7, purinergic receptor P2X7 variant A, purnergic receptor P2X 7,)
• NCBI Gene ID: 5027
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99572
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

purinergic receptor P2X 7 interacts with:

• calcium/calmodulin dependent serine protein kinase
  cysteine rich tail 1
  EGF containing fibulin extracellular matrix protein 2
  heat shock transcription factor 2 binding protein
  keratin associated protein 10-8
  NBPF member 19
  notch 2 N-terminal like A
  obscurin like cytoskeletal adaptor 1
  pannexin 1
  pleckstrin homology and FYVE domain containing 2
  supervillin
  transmembrane 9 superfamily member 1
  tripartite motif containing 27
  zinc finger protein 655

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.