PCCA, propionyl-CoA carboxylase subunit alpha

PCCA, propionyl-CoA carboxylase subunit alpha

• The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

• Gene Synonyms (propionyl-CoA carboxylase alpha chain, mitochondrial, PCCase alpha subunit, pccA complementation group, propanoyl-CoA:carbon dioxide ligase alpha subunit, propionyl CoA carboxylase, alpha polypeptide, propionyl Coenzyme A carboxylase, alpha polypeptide, propionyl-CoA carboxylase alpha subunit,)
• NCBI Gene ID: 5095
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P05165
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

propionyl-CoA carboxylase subunit alpha interacts with:

• acyl-CoA synthetase medium chain family member 5
  anterior gradient 2, protein disulphide isomerase family member
  arginyl-tRNA synthetase 2, mitochondrial
  CXXC finger 1 (PHD domain)
  DDB1 and CUL4 associated factor 15
  dynactin subunit 4
  dynein light chain Tctex-type 1
  ERBB receptor feedback inhibitor 1
  H4 clustered histone 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  hook microtubule tethering protein 1
  hook microtubule tethering protein 3
  inositol hexakisphosphate kinase 3
  isoprenylcysteine carboxyl methyltransferase
  listerin E3 ubiquitin protein ligase 1
  lysosomal associated membrane protein 3
  N-terminal glutamine amidase 1
  nuclear receptor subfamily 2 group C member 2
  nucleoporin 155
  phosphatase and tensin homolog
  praja ring finger ubiquitin ligase 1
  propionyl-CoA carboxylase subunit beta
  protein phosphatase 2, regulatory subunit B'', alpha
  ring-box 1
  serum/glucocorticoid regulated kinase 1
  tetratricopeptide repeat domain 1
  thrombospondin 3
  tripartite motif containing 14
  tumor protein p53
  ubiquitin C
  ubiquitin conjugating enzyme E2 N
  ybeY metalloendoribonuclease
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.