PGGT1B, protein geranylgeranyltransferase type I subunit beta

PGGT1B, protein geranylgeranyltransferase type I subunit beta

• Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]

• Gene Synonyms (geranylgeranyl transferase type-1 subunit beta, CTC-428G20.3, GGTase-I-beta, geranylgeranyl transferase type I subunit beta, geranylgeranyltransferase type I beta subunit, protein geranylgeranyltransferase type I, beta subunit, type I protein geranyl-geranyltransferase subunit beta, BGGI, GGTI,)
• NCBI Gene ID: 5229
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P53609
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein geranylgeranyltransferase type I subunit beta interacts with:

• AKT interacting protein
  AMMECR1 like
  EH domain containing 1
  G protein subunit gamma 2
  hes related family bHLH transcription factor with YRPW motif like
  phosphodiesterase 12
  RAS related 2
  signal transducer and activator of transcription 6
  SLIT-ROBO Rho GTPase activating protein 3
  testis specific serine kinase substrate
  ubiquitin like modifier activating enzyme 6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.