S1PR5, sphingosine-1-phosphate receptor 5

S1PR5, sphingosine-1-phosphate receptor 5

• The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]

• Gene Synonyms (sphingosine 1-phosphate receptor 5, S1P receptor 5, S1P receptor Edg-8, endothelial differentiation G-protein-coupled receptor 8, endothelial differentiation, sphingolipid G-protein-coupled receptor, 8, sphingosine 1-phosphate receptor EDG8, sphingosine 1-phosphate receptor Edg-8, EDG8, Edg-8, S1P5, SPPR-1, SPPR-2,)
• NCBI Gene ID: 53637
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H228
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sphingosine-1-phosphate receptor 5 interacts with:

• LY6/PLAUR domain containing 6
  serine rich single-pass membrane protein 1
  solute carrier family 39 member 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.