PNMT, phenylethanolamine N-methyltransferase

PNMT, phenylethanolamine N-methyltransferase

• The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

• Gene Synonyms (phenylethanolamine N-methyltransferase, noradrenaline N-methyltransferase, phenylethanolamine N-methylase, PENT, PNMTase,)
• NCBI Gene ID: 5409
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A8MT87
  UNIPROT ID#>>P11086
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phenylethanolamine N-methyltransferase interacts with:

• kelch like family member 8
  ligand of numb-protein X 1
  mitogen-activated protein kinase kinase 2
  RELA proto-oncogene, NF-kB subunit
  ribosomal protein S6 kinase A4
  telomeric repeat binding factor 1
  TERF2 interacting protein
  uridine-cytidine kinase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.