P4HTM, prolyl 4-hydroxylase, transmembrane

P4HTM, prolyl 4-hydroxylase, transmembrane

• The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

• Gene Synonyms (transmembrane prolyl 4-hydroxylase, HIF-PH4, HIF-prolyl hydroxylase 4, HPH-4, P4H with transmembrane domain, Prolyl hydroxlase domain-containing 4, hypoxia-inducible factor prolyl 4-hydroxylase, hypoxia-inducible factor prolyl hydroxylase 4, proline 4-hydroxylase, prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum), EGLN4, HIDEA, HIFPH4, P4H-TM, PH-4, PH4, PHD4,)
• NCBI Gene ID: 54681
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NXG6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

prolyl 4-hydroxylase, transmembrane interacts with:

• protein disulfide isomerase family A member 2
  ras homolog family member U

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.