ARMC4, armadillo repeat containing 4

ARMC4, armadillo repeat containing 4

• The protein encoded by this gene contains ten Armadillo repeat motifs (ARMs) and one HEAT repeat, and is thought to be involved in ciliary and flagellar movement. This protein has been shown to localize to the ciliary axonemes and at the ciliary base of respiratory cells. Studies indicate that mutations in this gene cause partial outer dynein arm (ODA) defects in respiratory cilia. The cilia of cells with mutations in this gene displayed either reduced ciliary beat frequency and amplitude, or, complete immotility. Some individuals with primary ciliary dyskensia (PCD) have been shown to have mutations in this gene. PCD is characterized by chronic airway disease and left/right body asymmetry defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

• Gene Synonyms (armadillo repeat-containing protein 4, testis tissue sperm-binding protein Li 74n, CILD23, gudu,)
• NCBI Gene ID: 55130
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VKF7
  UNIPROT ID#>>Q5T2S8
  UNIPROT ID#>>B7Z7Y0
  UNIPROT ID#>>B7Z7A1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

armadillo repeat containing 4 interacts with:

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