NUDT15, nudix hydrolase 15

NUDT15, nudix hydrolase 15

• This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]

• Gene Synonyms (MTH2, NUDT15D, nucleotide triphosphate diphosphatase NUDT15, 8-oxo-dGTPase NUDT15, mutT homolog 2, nucleoside diphosphate-linked to another moiety X hydrolase 15, nudix (nucleoside diphosphate linked moiety X)-type motif 15, probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15, probable 8-oxo-dGTP diphosphatase NUDT15,)
• NCBI Gene ID: 55270
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NV35
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nudix hydrolase 15 interacts with:

• colipase like 1
  leucine zipper tumor suppressor 2
  lipocalin 15
  pleckstrin homology domain containing A4
  steroid 5 alpha-reductase 3
  TNFAIP3 interacting protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.