PRH1, proline rich protein HaeIII subfamily 1

PRH1, proline rich protein HaeIII subfamily 1

• This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. Multiple distinct alleles of this locus including the parotid isoelectric-focusing variant slow (PIF-s), the parotid acidic protein (Pa), and the double band slow (Db-s) isoforms have been characterized. The reference genome encodes the Db-s allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Co-transcription of this gene with adjacent genes has been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

• Gene Synonyms (salivary acidic proline-rich phosphoprotein 1/2, PRP-1/PRP-2, parotid acidic protein, parotid double-band protein, parotid isoelectric focusing variant protein, parotid proline-rich protein 1/2, protein C, Db-s, PA, PIF-S, PRH2, Pr1/Pr2,)
• NCBI Gene ID: 5554
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P02810
  UNIPROT ID#>>A0A087WV42
  UNIPROT ID#>>F1T0A8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proline rich protein HaeIII subfamily 1 interacts with:

• G protein-coupled receptor 37 like 1
  mitochondrial translational initiation factor 3
  protein tyrosine phosphatase non-receptor type 20
  spindle apparatus coiled-coil protein 1
  tachykinin precursor 3
  transmembrane and coiled-coil domains 5A
  transmembrane protein 14B

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