PRR5, proline rich 5

PRR5, proline rich 5

• This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]

• Gene Synonyms (FLJ20185k, PP610, PROTOR-1, PROTOR1, proline-rich protein 5, Rho GTPase activating protein 8, proline rich 5 (renal), protein observed with Rictor-1,)
• NCBI Gene ID: 55615
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A8K699
  UNIPROT ID#>>A0A024R4U5
  UNIPROT ID#>>P85299
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proline rich 5 interacts with:

• G protein signaling modulator 3
  MAPK associated protein 1
  MTOR associated protein, LST8 homolog
  RPTOR independent companion of MTOR complex 2
  USH1 protein network component harmonin binding protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.