- Gene Overview
- Interaction Network
- Sequence Verification
CFC1, cripto, FRL-1, cryptic family 1
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This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. The protein encoded by this gene is necessary for patterning the left-right embryonic axis. Mutations in this gene are associated with defects in organ development, including autosomal visceral heterotaxy and congenital heart disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
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Gene Synonyms (CFC1B, CRYPTIC, DTGA2, HTX2, cryptic protein, cryptic family protein 1, heterotaxy 2 (autosomal dominant),)
- NCBI Gene ID:
55997
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>P0CG37
UNIPROT ID#>>A0A087WX98
UNIPROT ID#>>A0A087WWV2
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
cell. Learn more about other interacting partners.
cripto, FRL-1, cryptic family 1 interacts with:
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how a sequence matches to an experimentally-validated ORF clone.
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