- Gene Overview
- Interaction Network
- Sequence Verification
PCDHA7, protocadherin alpha 7
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This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
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Gene Synonyms (CNR4, CNRN4, CNRS4, CRNR4, PCDH-ALPHA7, protocadherin alpha-7, KIAA0345-like 7, PCDH-alpha-7, ortholog to mouse CNR4,)
- NCBI Gene ID:
56141
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>Q9UN72
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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protocadherin alpha 7 interacts with:
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