- Gene Overview
- Interaction Network
- Sequence Verification
PCDHA5, protocadherin alpha 5
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This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
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Gene Synonyms (CNR6, CNRN6, CNRS6, CRNR6, PCDH-ALPHA5, protocadherin alpha-5, KIAA0345-like 9, PCDH-alpha-5, ortholog of mouse CNR6,)
- NCBI Gene ID:
56143
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>Q9Y5H7
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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protocadherin alpha 5 interacts with:
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