PRODH, proline dehydrogenase 1

PRODH, proline dehydrogenase 1

• This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

• Gene Synonyms (proline dehydrogenase 1, mitochondrial, p53-induced gene 6 protein, proline dehydrogenase (oxidase) 1, proline oxidase 2, proline oxidase, mitochondrial, tumor protein p53 inducible protein 6, HSPOX2, PIG6, POX, PRODH1, PRODH2, TP53I6,)
• NCBI Gene ID: 5625
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43272
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proline dehydrogenase 1 interacts with:

• BRCA1 associated protein
  calpain 11
  solute carrier family 23 member 3
  thiosulfate sulfurtransferase
  tubulin alpha 4a

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.