PRRG2, proline rich and Gla domain 2

PRRG2, proline rich and Gla domain 2

• The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

• Gene Synonyms (transmembrane gamma-carboxyglutamic acid protein 2, proline rich Gla (G-carboxyglutamic acid) 2, proline-rich Gla (G-carboxglutamic acid) polypeptide 2, proline-rich Gla (G-carboxyglutamic acid) polypeptide 2, proline-rich Gla protein 2, proline-rich gamma-carboxyglutamic acid protein 2, PRGP2,)
• NCBI Gene ID: 5639
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14669
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proline rich and Gla domain 2 interacts with:

• BAG cochaperone 3
  family with sequence similarity 221 member A
  fetal and adult testis expressed 1
  small glutamine rich tetratricopeptide repeat containing alpha
  Yes1 associated transcriptional regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.