- Gene Overview
- Interaction Network
- Sequence Verification
EPPIN, epididymal peptidase inhibitor
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This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
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Gene Synonyms (CT71, CT72, SPINLW1, WAP7, WFDC7, dJ461P17.2, eppin, WAP four-disulfide core domain protein 7, cancer/testis antigen 71, cancer/testis antigen 72, epididymal protease inhibitor, epididymis secretory sperm binding protein, protease inhibitor WAP7, serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin),)
- NCBI Gene ID:
57119
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>B2R4Q0
UNIPROT ID#>>O95925
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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epididymal peptidase inhibitor interacts with:
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