HAMP, hepcidin antimicrobial peptide

HAMP, hepcidin antimicrobial peptide

• The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014]

• Gene Synonyms (HEPC, HFE2B, LEAP1, PLTR, hepcidin, hepcidin preproprotein, liver-expressed antimicrobial peptide 1, putative liver tumor regressor,)
• NCBI Gene ID: 57817
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P81172
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

hepcidin antimicrobial peptide interacts with:

• vitamin K epoxide reductase complex subunit 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.