RASGRF1, Ras protein specific guanine nucleotide releasing factor 1

RASGRF1, Ras protein specific guanine nucleotide releasing factor 1

• The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]

• Gene Synonyms (ras-specific guanine nucleotide-releasing factor 1, Ras-specific guanine nucleotide-releasing factor, CDC25 homolog, Ras-specific nucleotide exchange factor CDC25, guanine nucleotide exchange factor, guanine nucleotide-releasing factor 1, guanine nucleotide-releasing factor, 55 kD, guanine nucleotide-releasing protein, CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1,)
• NCBI Gene ID: 5923
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IUU5
  UNIPROT ID#>>A8K270
  UNIPROT ID#>>Q13972
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Ras protein specific guanine nucleotide releasing factor 1 interacts with:

• EH domain containing 4
  protein phosphatase 1 regulatory subunit 9B
  RAS related 2
  small nuclear ribonucleoprotein U1 subunit 70
  SRC proto-oncogene, non-receptor tyrosine kinase
  SRSF protein kinase 2
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine kinase non receptor 2
  ubiquitin specific peptidase 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.