ARID4A, AT-rich interaction domain 4A

ARID4A, AT-rich interaction domain 4A

• The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]

• Gene Synonyms (AT-rich interactive domain-containing protein 4A, ARID domain-containing protein 4A, AT rich interactive domain 4A (RBP1-like), retinoblastoma-binding protein 1, RBBP-1, RBBP1, RBP-1, RBP1,)
• NCBI Gene ID: 5926
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P29374
  UNIPROT ID#>>A0A024R6A2
  UNIPROT ID#>>A0A024R657
  UNIPROT ID#>>A0A024R680
  UNIPROT ID#>>Q05CG0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

AT-rich interaction domain 4A interacts with:

• AT-rich interaction domain 4B
  BRMS1 transcriptional repressor and anoikis regulator
  clusterin associated protein 1
  EP300 interacting inhibitor of differentiation 1
  forkhead box K1
  GATA zinc finger domain containing 1
  H2B clustered histone 8
  H3 clustered histone 14
  H4 clustered histone 1
  H4 histone 16
  histone deacetylase 3
  HMG-box transcription factor 1
  macroH2A.1 histone
  RB binding protein 4, chromatin remodeling factor
  RB binding protein 7, chromatin remodeling factor
  RB transcriptional corepressor like 1
  SIN3 transcription regulator family member A
  SIN3 transcription regulator family member B
  Sin3A associated protein 30
  SIN3-HDAC complex associated factor
  SIN3-HDAC complex associated factor
  transcriptional regulator, SIN3A (yeast)
  zinc finger protein 704

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.