CCL18, C-C motif chemokine ligand 18

CCL18, C-C motif chemokine ligand 18

• This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]

• Gene Synonyms (C-C motif chemokine 18, CC chemokine PARC, CC chemokine ligand 18, alternative macrophage activation-associated CC chemokine 1, chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated), chemokine (C-C), dendritic, dendritic cell chemokine 1, macrophage inflammatory protein 4, pulmonary and activation-regulated chemokine, small inducible cytokine A18, small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated, AMAC-1, AMAC1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18,)
• NCBI Gene ID: 6362
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P55774
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

C-C motif chemokine ligand 18 interacts with:

• ergosterol biosynthesis 28 homolog
  TLE family member 1, transcriptional corepressor
  tumor protein p53
  unc-119 lipid binding chaperone

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.