NEK4, NIMA related kinase 4

NEK4, NIMA related kinase 4

• The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]

• Gene Synonyms (serine/threonine-protein kinase Nek4, NIMA (never in mitosis gene a)-related kinase 4, never in mitosis A-related kinase 4, nimA-related protein kinase 4, serine/threonine kinase 2, serine/threonine protein kinase-2, serine/threonine-protein kinase NRK2, serine/threonine-protein kinase Nek4 variant 2, NRK2, STK2, pp12301,)
• NCBI Gene ID: 6787
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P51957
  UNIPROT ID#>>Q05DF6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NIMA related kinase 4 interacts with:

• ankyrin repeat domain 28
  COBW domain containing 1
  COBW domain containing 2
  CTD small phosphatase 2
  exportin 1
  glycosylated lysosomal membrane protein
  lysosomal associated membrane protein 3
  nephrocystin 4
  pleckstrin homology domain containing A4
  protocadherin alpha 12
  protocadherin beta 11
  protocadherin gamma subfamily B, 1
  RPGR interacting protein 1
  RPGRIP1 like
  sperm acrosome associated 1
  src kinase associated phosphoprotein 1
  stromal cell derived factor 4
  thioredoxin domain containing 15
  tubulin alpha 3c
  tubulin beta 1 class VI
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.